Concerns About Potential Toxicities
The Hutch scientists note, however, that the good news is tempered by recent concerns within the gene therapy field about the potential for therapies using AAVs to cause liver and nerve damage.
The toxicity issue has been raised by other gene therapy researchers based on their own experiments. It does not appear to involve the gene-cutting enzymes used in the Hutch herpes studies, where those molecular scissors are performing as expected. Instead, it focuses on the AAVs used to package and transport them.
âAAV vectors in general have been considered quite safe. ⦠However, emerging work has suggested that AAV vectors may not be as fully innocuous as previously assumed,â the Hutch authors wrote in the bioRxiv paper.
They observed liver toxicity in some of their mice, but said it seems to be the result of very high concentrations of AAV, well above what is now known to be needed.
âWe know what the toxic dose is, and we get good results below that,â Jerome said.
The neurotoxicity is potentially more concerning. The Hutch team reported âsubtle evidence of neuronal injuryâ in mice when tissue samples were examined under a powerful microscope. However, they also saw no evidence in those animals of changes in behavior or mobility â such as gait or balance disturbances â after the gene therapy.
A priority in the next round of research will be to solve that mystery and, if necessary, find a way around it. The researchers remain confident the problem is solvable.
Herpes Cure Needs Free To Choose Medicine
Friday, August 18, 2017
Until recent weeks, I knew almost nothing about herpes. The few people Ive known who admitted they had it didnt want to talk any more about it. Because of a longstanding and unfortunate stigma attached to the disease, far more people have it than most of us would ever suspect. Many around the world with severe cases suffer an agonizing ordeal in hopeless silence.
This is not a story, however, without hope. Quite the contrary. Thanks to a remarkable man who passed away on June 22, 2017 at the untimely age of 48, relief from the scourge of herpes may soon be a reality.
Hope for a Herpes Cure
For the sake of the many who suffer from the disease of herpes, its now up to the rest of us. This is a story about a genius who challenged conventional wisdom, blazed new trails in scientific research, dedicated his life to helping others, developed promising new tools against a terrible affliction, and lighted a path for the policy changes needed to end the suffering of millions. His name was Dr. William P. Halford.
Now that Ive come to know the Halford story, regrettably too late to have met the man himself, I feel compelled to share it with as many people as possible. I hope you will find it as motivational as it has become for me. More on Dr. Halford in a moment, but first a few words about the chronic and unrelenting contagion he did so much in his short life to defeat.
The Good Doctor
Free to Choose Medicine
Herpes Treatment The Perfect Solution For Hsv Is Hekma Hsv Package: The Story Of Ms Sy
It is difficult to accept a disease you did not expect, which may stay with you for life because there is no solution in modern medicine, and you are still young. Here is the story of Ms. SY, who was cured of herpes virus using the perfect HSV formula.
Ms. SY contacted our staff via WhatsApp to inquire about the herpes package on August 30, 2021.
SY purchased the package and was eagerly waiting for it to arrive to begin her journey.
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Risks And Side Effects
The three main treatments for herpes acyclovir, famciclovir, and valacyclovir are all FDA approved, though there are side effects and interactions to be aware of.
Common side effects of these antiviral medications include headaches and nausea. Famciclovir can cause dizziness or sleepiness, and confusion is mainly seen in older adults.
Acyclovir and valacyclovir, which are very similar to each other, can cause your kidneys to stop working. If you have kidney issues, your doctor may prescribe a lower dose. These medications can interact with other medications, such as nonsteroidal anti-inflammatory drugs like ibuprofen. This may weaken kidney function.
Best For Skin Barrier: Vaseline 100% Pure Petroleum Jelly
- Price: $3.2917.70
- Pros: available in a range of sizes, suitable for sensitive skin
- Cons: reports of product hygiene issues from online sellers
A person can purchase Vaseline online through Amazon.
Vaseline states it is hypoallergenic and suitable for sensitive, dry skin.
It also claims that its product helps seal in moisture, which may help the skin heal naturally. Additionally, petroleum jelly creates a barrier between the skin and outside elements.
This Vaseline product may be best suited to people with cold sores.
Vaseline costs between $3.2917.70, depending on the tub size.
Pros: suitable for smaller budgets, high volume per bottle, third-party testedCons: limited research into the effectiveness of L-lysine for herpes
These caplets are suitable for vegetarians and free of allergens such as yeast, wheat, gluten, milk, and lactose. They are also free of sugar.
CVS Pharmacy claims these caplets may help support healthy skin, collagen production, and tissue maintenance.
CVS states it requires third-party testing for all supplements.
The company recommends taking one caplet a day on an empty stomach. Each pill contains 1,000 mg of L-lysine.
CVS Pharmacy L-Lysin Caplets cost $11.29.
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Billions Worldwide Living With Herpes
About half a billion people worldwide are living with genital herpes, and several billion have an oral herpes infection, new estimates show, highlighting the need to improve awareness and scale up services to prevent and treat herpes.
About 13% of the worlds population aged 15 to 49 years were living with herpes simplex virus type 2 infection in 2016, the latest year for which data is available. HSV-2 is almost exclusively sexually transmitted, causing genital herpes. Infection can lead to recurring, often painful, genital sores in up to a third of people infected.
Herpes simplex virus type 1 is mainly transmitted by oral to oral contact to cause oral herpes infection sometimes leading to painful sores in or around the mouth . However, HSV-1 can also be transmitted to the genital area through oral sex, causing genital herpes.
Around 67% of the worlds population aged 0 to 49 had HSV-1 infection in 2016 an estimated 3.7 billion people. Most of these infections were oral however, between 122 million to 192 million people were estimated to have genital HSV-1infection.
Genital herpes is a substantial health concern worldwide beyond the potential pain and discomfort suffered by people living with the infection, the associated social consequences can have a profound effect on sexual and reproductivehealth says Dr Ian Askew, Director of the Department of Sexual and Reproductive Health and Research at the World Health Organization .
How Does Genital Herpes Spread
Herpes can be spread when an infected person has lesions blisters and open sores on their body or when you do not have any symptoms. Taking antiviral medicine can help you reduce the risk of spreading genital herpes to your sexual partners. You can also:
- Inform your sexual partner that you have genital herpes.
- Use a condom every time you have sex.
- Refrain from having sex when you have symptoms.
- Abstain from performing oral sex if you have blisters or open sores around your mouth.
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Is There Any Resistance To Genital Herpes Medication
Resistance to drugs that treat genital herpes even after 20 years of use is very rare. Herpes medications may not work as well in patients who are very immunosuppressed and have been treated with these drugs for a long time. Each individuals response to treatment may vary. In some cases, patients may need more drugs to suppress their viral outbreaks than others.
What Are The Different Types Of Herpes
There are two types of herpes simplex virus: HSV I and HSV II. HSV I commonly causes oral herpes, or cold sores. This virus can show up as an upper respiratory tract infection during early childhood. HSV II is the cause of most cases of genital herpes. However, it is possible for HSV I to cause genital herpes and HSV II to cause oral herpes.
Clinicians cannot tell the difference between the two types by physical examination alone, but there are differences between the two viruses. For example, genital herpes caused by HSV II is much more likely to recur. This diagnosis can be helpful in establishing a health care plan.
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Is Genital Herpes Infection Related To Hiv
Herpes and HIV are caused by different viruses. But patients infected with these viruses are more likely to transmit either disease to their sexual partners. Patients with herpes are more vulnerable to HIV infection. People newly diagnosed with herpes should be tested for HIV infection and other sexually transmitted infections.
Patients who are infected with both herpes and HIV also may have a higher concentration of HIV viruses in their body because of the interaction between the herpes virus and the HIV virus. When HIV damages a persons immune system, the person may be more likely to shed herpes simplex virus asymptomatically.
Herpes Vaccine Difficulties During Development
As per studies, a major difficulty in developing a herpes vaccine is connected to the way alpha-herpesviruses including HSV have evolved a complex mechanism to evade immune responses that could destroy them. The HSV first infects the mucosal tissues of the mouth or genitourinary tract. Then it works its way to the tips of the sensory nerves that transmit signals that are responsible for sensations such as touch and pain. The virus then breaks into the nerve cell with the help of a molecular switch. It uses the molecules to travel along nerve fibers and into the nucleus of the sensory neuron. These infected neurons become essentially a hiding spot for the virus while the infection is cleared by the immune response.
The breakthrough discovery that the HerpaGreens supplement is based on, was made in a study conducted in 2014 by a team led by Thomas Christie, a chief scientist of molecular genetics at the National Institute of Allergy and Infectious Diseases. The team discovered that a drug called Tranylcypromine or TCP could block a protein called LSD-1. This is the exact protein that helps the herpes virus to hide from the immune system.
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If You Have Genital Herpes Already Can It Be Spread To Other Parts Of The Body Such As The Arms Or Legs
No. Genital herpes cannot be transmitted to another part of your body such as your arm, leg or hand after the first infection occurs. If you have genital HSV II, you will not get HSV II at another site in your body. The immune system produces antibodies that protect other parts of your body from infection. However, there are cases where a person has multiple site infections from the same virus. This is usually acquired at the time of the first infection. For example, if someone has never had herpes but then has oral and genital sex with an infected partner, they can acquire the infection at both sites.
Herpes Vaccine To Be Tested In Humans After Best Result Yet In Animals
A vaccine for herpes could be on the horizon
Jonnie Miles/Getty Images
Hopes have been raised that we will soon have a vaccine to halt the spread of genital herpes, following an animal study that has achieved better results than any previous trial. More than 1 in 10 people worldwide are infected by the virus.
Most people never realise they are infected but others suffer from outbreaks of painful symptoms, including genital lesions. The virus can also cause complications such as meningitis, and is occasionally passed on to babies during birth with fatal results.
People are most infectious when they have genital lesions but even those with no symptoms often still shed the virus and can infect others.
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Sharing My Experience For Dealing With And Decreasing Cold Sore Outbreaks Hope It Helps
Hi everyone! I used to struggle with major outbreaks of cold sores for pretty much the majority of my life and thought I would share my story/what I did to stop outbreaks . Of course ymmv but I hope this will help someone.
Background: I had cold sores since my childhood. I didnt have a strong immune system growing up which I eventually addressed but even after that I still kept getting outbreaks. Took a good amount of antibiotics as a kid for various sicknesses and had some gastrointestinal issues. During my teenage and young adult years, especially during winters, its like I literally always had an outbreak. It was a disaster. Finally 15 years later I figured out how to address it. 2 years ago I took quite a few steps and have seen amazing results since.
Also, if youre reading this and feeling as desperate/dreadful/demoralized as I was, Im sorry you have to deal with this, Ive felt the pain. I empathize and sincerely hope your situation gets better!
First, heres what worked best for me during an outbreak:
· Virulite: I bought this on for like $100. Ive never used it by itself without any of the other methods so its hard to say whether it actually works, but its definitely not as effective as the dental laser. I havent tried Luminance Red.
· Vitamin C: took an obnoxious amount of this throughout the winter but especially during outbreaks and it seemed to help. You could also try putting the paste or a Vitamin C serum on the sore.
If Glycoprotein D Is Needed For Viral Cell Entry How Does A Gd
HSV-2 contains a protein on its surface known as glycoprotein D which it needs to enter host cells. It is also essential for cell-to-cell spread of the virus. If the gD gene is deleted from HSV-2 and the virus is grown using a cell line that provides the HSV-1 gD protein to complement the missing surface protein, a hybrid virus is produced that is restricted to a single cycle of growth. When vaccinated, the gD-1 complemented HSV-2 virus replicates once, however the non-infectious progeny cannot spread from cell to cell as it lacks the gene that codes for glycoprotein D.
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What Results Have You Seen That Support The Clinical Development Of Gd
Extensive molecular and pre-clinical work has been completed for gD-2, which induces immunity against both HSV-1 and HSV-2 challenge in multiple pre-clinical models. Not only did the candidate prevent disease, but gD-2 also prevented the virus from reactivation. Latency refers to the ability of the herpes virus to remain dormant particularly in nerve tissue, often establishing lifelong infection with frequent subclinical or clinical reactivation.
In multiple preclinical models we demonstrated that vaccination with gD-2 completely protects from herpes disease and reactivation protection is strongly correlated with the formation of ADCC antibodies mediating the killing of infected cells and thereby blocking viral spread.
Further Considerations For The Future Of Herpes Simplex Virus Vaccine Development
Our understanding of the complexities of herpes simplex virus pathogenesis and immune evasion is consistently evolving, along with our understanding of viral latency. Designing an effective therapeutic or prophylactic vaccine requires further understanding these processes.
Trials that had been successful in the pre-clinical realm with murine model and guinea pig models have been effective, but have not translated well in the clinical realm. Other trials like the GSK gD subunit vaccine and the GEN-003 vaccine have been suspended due to dwindling financial support . To us, the HSV-529 and G103 appear to be promising from early studies in the pre-clinical stage. Additionally, they are likely to have less issues with safety as they are not live-attenuated vaccines.
The rapid development of an mRNA vaccine for COVID-19 has re-vitalized interest in mRNA vaccines as viable options to produce viral immunity. The classical problems involving the creation of mRNA vaccines include mRNA stability and delivery systems. It remains to be seen whether mRNA vaccines might have a utility for HSV however, initial studies with the trivalent vaccine have been promising, showing increased efficacy compared to a subunit formulation .
The advantages of an mRNA vaccine were previously discussed: It does not integrate within the host genome, translates in both proliferating and non-proliferating cells, with immediate protein production for a controllable amount of time .
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Can I Still Have Sex If I Have Herpes
If you have herpes, you should talk to your sex partner about their risk. Using condoms may help lower this risk but it will not get rid of the risk completely. Having sores or other symptoms of herpes can increase your risk of spreading the disease. Even if you do not have any symptoms, you can still infect your sex partners.
You may have concerns about how genital herpes will impact your health, sex life, and relationships. While herpes is not curable, it is important to know that it is manageable with medicine. Daily suppressive therapy can lower your risk of spreading the virus to others. Talk to a healthcare provider about your concerns and treatment options.
A genital herpes diagnosis may affect how you will feel about current or future sexual relationships. Knowing how to talk to sexual partners about STDs is important.
How To Protect Yourself From Herpes
Aside from not having sex, there is no 100% effective way to prevent herpes. You can reduce the risk of contracting the infection by using a condom, but even a condom is not foolproof, as the virus can be transmitted even if your partner has no visible sores.
That said, if you or your partner has herpes, taking antiviral medications can significantly reduce the chances of transmission.
If you exhibit any of the symptoms of genital herpes, such as cracked, red sores around your genitals or rectum, ask your doctor for a blood test to detect HSV antibodies. Even if you test negative, regular STI screening is important for anyone who is sexually active, and free and low-cost testing resources can be found on the CDC’s website.
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