Valacyclovir Vs Acyclovir Vs Famciclovir: The Facts
Medically reviewed by Patrick Carroll, MD
There are several drugs used to treat herpes, all of which are antiviral medications. Some of the most popular, effective and widely used herpes medications currently available are valacyclovir , acyclovir and famciclovir . All of these drugs work through a similar mechanism, and all have their place in treating cases of HSV-1 and HSV-2.
In this guide, comparing valacyclovir vs. acyclovir vs. famciclovir to explain which one is the best choice for treating and managing the virus.
Dosage: How Much Valtrex Should I Take
The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form :
- For treatment of chickenpox:
- Adults and children below 2 years of ageUse and dose must be determined by your doctor.
- Children 2 to 18 years of ageDose is based on body weight and must be determined by your doctor. The usual dose is 20 milligrams per kilogram of body weight, taken three times a day for 5 days. However, the dose is usually not more than 1000 mg three times a day.
- For treatment of cold sores:
- Adults2000 milligrams every 12 hours for one day.
- Children 12 years of age and above2000 milligrams every 12 hours for one day.
- Children below 12 years of ageUse and dose must be determined by your doctor.
- For treatment of genital herpes, first outbreak:
- Adults1000 milligrams two times a day for ten days.
- ChildrenUse and dose must be determined by your doctor.
Which Herpes Medication Is Best
In the war between valacyclovir vs. acyclovir vs. famciclovir, the truth is, there is no best herpes medication. All three of the drugs are safe and proven to be effective as treatments for HSV-1, HSV-2, shingles and other forms of the herpes virus.
If you think you might have herpes, the best approach is to speak to your doctor about treatment options. Your doctor will be able to provide advice on the most effective drug for treating herpes based on your symptoms, immune system, lifestyle and overall health.
This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standardshere.
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Other Uses For This Medicine
Acyclovir is also sometimes used to treat eczema herpeticum to treat and prevent herpes infections of the skin, eyes, nose, and mouth in patients with human immunodeficiency virus , and to treat oral hairy leukoplakia .
This medication may be prescribed for other uses ask your doctor or pharmacist for more information.
Are Antiviral Medications Safe
Antiviral medications are considered to be very safe. They are nearly always well tolerated because the active ingredients only have an effect in cells that have been infected by the virus.
People who have kidney failure may need to take a lower dose because the medication is removed from the body through the kidneys.
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How Far Away Is A Cure For Herpes
Theres currently no cure for herpes, but that might change in the future.
According to 2020 research published in Nature, scientists from the Fred Hutchinson Cancer Research Center removed 90 percent of the HSV-1 virus from cells in mice using gene editing.
However, it takes time to transition potential treatments from animals to humans. In a 2020 news article, one of the researchers that authored the Nature paper estimated that it would be at least 3 years before human trials.
Scientists are also researching the possibility of creating a vaccine to prevent herpes. A 2022 study outlined a new approach to developing an mRNA vaccine for herpes. The vaccine mentioned in the study worked well in mice and guinea pigs.
The researchers say that theyre aiming to conduct human trials before the end of 2022, and the vaccine could be available within the next 10 years.
How Is Genital Herpes Diagnosed
Wherever possible, it is better to get any symptoms of genital herpes checked at a genitourinary medicine clinic/sexual health clinic. If you cannot get to a GUM clinic, then see your GP.
It is easier for your GUM specialists to diagnose genital herpes, while you have got the blisters or sores. They will do a swab test .
While it is easier to test for herpes when the infection is active, sometimes the test can still be negative, even though you have all the symptoms. For this reason, the GUM specialist will also examine you and make a diagnosis based on what they see. If they are unsure and if the test is also negative, then you may have to wait to see if you have a recurrent outbreak to confirm whether the diagnosis should be herpes.
At the GUM clinic, you will probably be asked:
- if you have had sexually transmitted infections in the past
- about your history of sexual partners
- whether you get cold sores
- whether or not this is the first time you have had these symptoms
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After Herpes Treatment What Should I Expect
Remember that, as long as you keep them clean, the blisters/sores will scab and heal with time. They will not leave a scar. If this is your first herpes outbreak, you can expect to have four or five outbreaks over the next couple of years. These are known as recurrent outbreaks. They are usually much less severe than the first outbreak. Over time recurrent outbreaks become increasingly infrequent and milder. If you are concerned or distressed, speak to your doctor.
How Do Herpes Drugs Work
Herpes medications like valacyclovir, acyclovir and famciclovir belong to a class of medications called antiviral drugs.
Antiviral drugs are designed to inhibit the multiplication of viruses in the body. Unlike antibiotics, which eliminate the bacteria that cause infections, antiviral drugs simply control viral proliferation, rather than completely eliminating the target virus from the body.
None of the antiviral drugs on the market today can cure herpes. However, consistent use of an antiviral drug can make living with herpes much easier by speeding up healing after an outbreak and reducing your risk of transmitting the virus to other people.
Herpes drugs are taken for several reasons. People with active HSV-1 or HSV-2 infections can take them during outbreaks to control and treat their symptoms. Antiviral drugs are also used as part of suppressive therapy for herpes to reduce the severity and frequency of outbreaks.
Even people with asymptomatic herpes can benefit from using antiviral drugs to lower their risk of spreading the virus to other people through sexual or oral contact.
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When To Talk With A Doctor
Herpes isnt curable, but it can be treated with antiviral medications. These medications can reduce the severity of an outbreak.
If you suspect you have herpes, make an appointment with a doctor. Its also a good idea to talk with your doctor about a herpes screening if:
- your current or previous sexual partner has herpes
- youre planning to have sex with a new partner
- you had a risky sexual encounter
If youve already been diagnosed with herpes and youre currently experiencing an outbreak, the outbreak might go away without causing complications and without treatment.
However, its wise to make an appointment with your doctor if:
- the outbreak is particularly painful or unbearable
- youre experiencing symptoms of other STIs
- youre experiencing frequent, severe outbreaks
If youre sexually active, its a good idea to have regular STI screenings. You can book appointments for STI screenings with your doctors office. You could also try a local clinic, certain pharmacies, or Planned Parenthood.
To Use Buccal Acyclovir Follow These Steps:
If the delayed-release buccal tablet comes off within the first 6 hours of application, reapply the same tablet. If it still will not stick, then apply a new tablet. If you accidentally swallow the tablet within the first 6 hours of application, drink a glass of water and place a new tablet on your gum. If the tablet falls off or is swallowed 6 or more hours after application, do not apply a new tablet until your next regular time.
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What To Know About Antivirals
Antiviral medications can reduce the duration and severity of symptoms. During this time, the doctors prescribe antiviral medications such as acyclovir to reduce the severity of the symptoms.
The medication may also reduce the risk of spreading the virus to other areas of the body.
In some cases, a doctor may also recommend a regimen of antiviral medications to reduce the risk of transmitting the virus to a partner.
These medications are all taken orally and can help reduce the duration and severity of an outbreak.
What Is Neonatal Herpes
Neonatal herpes can be a very serious infection. Babies generally contract the virus from their birthing parent during childbirth even if the parent doesnt have active lesions. They may also get HSV-1 if an adult with an active cold sore kisses them. Breastfeeding babies can also get HSV-1 from the breast if there are lesions present. But babies cant get herpes from breast milk, so its safe to pump and feed.
Herpes simplex can be more dangerous for young babies because they dont have a fully developed immune system. But most babies with neonatal herpes can recover fully with treatment.
The dangers of neonatal herpes are much higher if the infection spreads to the babys organs. If youre pregnant and have herpes, speak with your healthcare provider about how to lower the risk of passing the infection to your baby.
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One Option For Ongoing Therapy: Taking Drugs Regularly
Some people with genital herpes choose to take antiviral medication daily to reduce the number of symptom outbreaks they have. In some cases, daily therapy prevents outbreaks completely.
Numerous studies over the years have demonstrated the safety and effectiveness of all three of the approved antivirals used to treat genital herpes.
Studies have also shown that daily antiviral therapy reduces the rate of transmission from an HSV-2 infected person to an uninfected partner of the opposite sex.
Daily therapy also lowers the odds of infecting other people if you have multiple sex partners or if you are a man who has sex with men.
The drugs work both for people who have had herpes symptoms and for those whose blood tests show they have an HSV-2 infection but who have never had symptoms.
Some people choose to take antiviral drugs only as needed, for outbreaks that occur after the first one. For this to work, you need to start taking the medicine within one day of sores cropping up or during the time period that comes before some outbreaks.
During the prodrome, you may feel
- Burning in the area where the virus first entered your body
- Itching or tingling in that area
- Pain in your back, buttocks, thighs, or knees
Your doctor will probably give you a prescription you can fill and keep handy for timely use, and tell you to start taking the drugs just as soon as symptoms begin.
What Is Valtrex Used For
The Food and Drug Administration approved Valtrex for the following indications:
- Genital herpes, usually caused by herpes simplex virus 2
- Prevention of transmission of HSV
- Suppression of HSV
- Suppression of HSV for people who are immunosuppressed due to human immunodeficiency virus
- Shingles, which is caused by reactivation of varicella zoster and produces a painful rash
The dosing of Valtrex differs for children and adults and is based on weight for the treatment of chicken pox. Valtrex is used short term for the treatment of chicken pox, shingles, and cold sores.
It can also be used for the short-term treatment of genital herpes or long term to suppress the virus and prevent transmission to a partner. However, it is important to remember that Valtrex will not cure your herpes infection completely.
Verywell / Dennis Madamba
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What Is Genital Herpes
Genital herpes is a common viral infection caused by a virus known as the herpes simplex virus .
There are two types of the virus, types 1 and 2 . As well as genital herpes, HSV can infect your mouth and cause cold sores. HSV-1 and HSV-2 infections look the same and you can only tell them apart by lab testing.
Because genital herpes can be passed to others through sexual contact, it is often referred to as a sexually transmitted infection .
As many as 1 in 3 adults has the virus that causes genital herpes. Once you have HSV it remains in your body and becomes active again from time to time.
On average, symptoms of genital herpes are likely to recur 45 times in the first 2 years after being infected with HSV. However, over time the virus tends to become active less often and each time you get symptoms they are less severe.
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When Treatments For Genital Herpes Are Given
- Initial treatment. If you have symptoms such as sores when you’re first diagnosed with genital herpes, your doctor will usually give you a brief course of antiviral therapy to relieve them or prevent them from getting worse. Your doctor may keep you on the drugs longer if the sores don’t heal in that time.
After the first treatment, work with your doctor to come up with the best way to take antiviral therapies. There are two options:
- Intermittent treatment. Your doctor may prescribe an antiviral drug for you to keep on hand in case you have another flare-up this is called intermittent therapy. You can take the pills for two to five days as soon as you notice sores or when you feel an outbreak coming on. Sores will heal and disappear on their own, but taking the drugs can make the symptoms less severe and make them go away faster.
- Suppressive treatment. If you have outbreaks often, you may want to consider taking an antiviral drug every day. Doctors call this suppressive therapy. For someone who has more than six outbreaks a year, suppressive therapy can reduce the number of outbreaks by 70% to 80%. Many people who take the antiviral drugs daily have no outbreaks at all.
There is no set number of outbreaks per year that doctors use to decide when someone should start suppressive therapy. Rather, more important factors are how often the outbreaks happen and if they are severe enough to interfere with your life.
Continued
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Topical Otc Treatments For Genital Herpes
Several over-the-counter topical options are available for genital herpes treatment, but evidence suggests they arent all effective.
Start with a few simple DIY topical compresses. Research shows that topical therapy can effectively alleviate symptoms of genital herpes outbreaks and even contribute to the prevention of outbreaks when used promptly.
Here are a few tried-and-true natural compress ideas to get you started:
- -Dry, warm compress using warmed rice in a sock
- -Cold compress using an ice pack or soft washcloth filled with ice
- -Baking soda paste
- -Crushed garlic cloves mixed with olive oil
- -Topical apple cider vinegar using one-part ACV and three-parts warm water
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What is genital herpes?
Herpes is a common sexually transmitted infection caused by the herpes simplex virus that is easily passed on by sexual contact. Unfortunately, once you have contracted herpes there is no known way to cure it. However, genital herpes can be managed and suppressed effectively if you use the right genital herpes treatment which you can buy online.
Herpes simplex virus type 2 causes the STI, while herpes simplex virus type 1 causes cold sore herpes, which is most likely to break out on the lips or face. This condition can be treated with aciclovir tablets and valaciclovir tablets. While type 2 herpes simplex virus usually causes genital herpes and type 1 affects the lips or face, type 1 herpes can also cause genital herpes due to more people having oral sex.
People who have herpes often report experiencing 4 or 5 different outbreaks a year, so make sure you have measures in place to keep these periods of time as comfortable as possible.
What are the symptoms of genital herpes?
When you experience herpes symptoms, the first episode is likely to be the worst. This may include:
- Fever or flu-like symptoms
After this initial outbreak, genital herpes symptoms are likely to become less severe as your body builds up more immunity to the herpes virus.
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