What Triggers Genital Herpes
A recurrence takes place when HSV reactivates in the nerve ganglion at the base of the spinal cord and particles of the herpes virus travel along the nerve to the site of the original herpes infection in the skin or mucous membranes . Sometimes, the herpes virus travels down a different nerve causing recurrent symptoms at another site such as the buttocks or thighs.
Although it is not known exactly why the herpes virus reactivates at various times, the cause can be separated into the physical and the psychological.
- Physical: Physical factors that have been anecdotally identified differ among people. Being run-down, suffering from another genital infection , menstruation, drinking too much alcohol, exposure of the area to strong sunlight, conditions that weaken the immune system, prolonged periods of stress or depression, are all factors that can trigger an episode. Less commonly, friction or damage to the skin, such as may be caused by lack of lubrication at the time of sexual intercourse, can lead to a recurrence. In summary, anything that lowers your immune system or causes local trauma can trigger recurrences.
- Psychological: Recent studies have demonstrated that periods of prolonged stress may precipitate more frequent recurrences. It is also common to experience stress and anxiety from having recurrences.
Genital Herpes Can Be Elusive
In many people, the diagnosis of genital herpes can be hard to establish.
The severity of herpes symptoms can vary greatly from one person to another. An initial episode can, at times, be so mild as to pass unnoticed and a first herpes recurrence may take place some months or even years after the first herpes infection.
Up to 80% of people who have been infected with genital herpes are unaware they have the herpes infection. These people may, however, transmit HSV to others.
In such cases genital herpes can lead to confusion and bewilderment in people, unable to understand the sudden appearance of the herpes infection and apparent transmission from someone else.
How Can The Virus Be Killed
The virus is readily killed in the environment by disinfectants, as long as the disinfectant contacts all contaminated surfaces. A bleach solution is an effective disinfectant for surface disinfection or for use on objects that can be bleached. Contaminated objects should be soaked in bleach solution for a minimum of 5 minutes. Blankets or toys can also be disinfected by regular machine washing using hot water and detergent. Objects that cannot be bleached may be decontaminated by thorough washing with plenty of soap and water. Upholstered furniture may be decontaminated with upholstery shampoo, although in most cases furniture only serves as a source of virus for a short period of time after being contaminated by an infected cat.
After touching an infected cat, hands can be sanitized by washing with soap and water , followed by application of an alcohol-based hand sanitizer.
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How Can This Disease Be Prevented
The standard core vaccines that are given to cats include a vaccine against feline viral rhinotracheitis. The FVR vaccine will not completely prevent an infection from occurring if your cat is exposed to the virus, but it will significantly reduce the severity of the infection and will shorten the length of the illness. Solid immunity to these viruses is not long term, and may be overcome by exposure to a high dose of virus. Therefore, the FVR vaccine needs to be boostered on a regular basis – your veterinarian will advise you on the recommended booster schedule for your individual cat, based on its lifestyle and risk of disease.
A cat that is a carrier of FVR may benefit from periodic boosters with the intranasal herpes and calicivirus vaccine , which may prevent reactivation of the virus, thus decreasing the likelihood of recurrent infection and of viral shedding.
Boarding facilities, humane societies, animal shelters, and cat shows are all places where susceptible cats can be readily exposed to these infectious diseases. If you plan on boarding or showing your cat, consult your veterinarian about the need for a booster vaccine at least two weeks before the planned event.
“The standard core vaccines that are given to cats include a vaccine against feline viral rhinotracheitis.”
If your cat has had an FVR infection, you should keep her indoors to prevent spread of this infection to other cats in your neighborhood.
Ready To Try Monolaurin But Not Sure Where To Start
There are many factors which should be considered when purchasing Monolaurin, which include:
What Monolaurin source is best – Coconut or Palm Kernel
What is the recommended way to take Monolaurin – Capsule or Pellet
What is an Excipient, and why does it matter – Synthetic or Natural
What hat to look for to ensure manufacturing safety – Certifications and Location
All of these questions can be answered in the comprehensive Monolaurin Buying Guide.
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How Is Genital Herpes Diagnosed
HSV nucleic acid amplification tests are the most sensitive and highly specific tests available for diagnosing herpes. However, in some settings viral culture is the only test available. The sensitivity of viral culture can be low, especially among people who have recurrent or healing lesions. Because viral shedding is intermittent, it is possible for someone to have a genital herpes infection even though it was not detected by NAAT or culture. 11
Type-specific virologic tests can be used for diagnosing genital herpes when a person has recurrent symptoms or lesion without a confirmatory NAAT, culture result, or has a partner with genital herpes. Both virologic tests and type-specific serologic tests should be available in clinical settings serving patients with, or at risk for, sexually transmitted infections. 11
Given performance limitations with commercially available type-specific serologic tests , a confirmatory test with a second method should be performed before test interpretation. If confirmatory tests are unavailable, patients should be counseled about the limitations of available testing before serologic testing. Healthcare providers should also be aware that false-positive results occur. In instances of suspected recent acquisition, serologic testing within 12 weeks after acquisition may be associated with false negative test results. 11
Providers are strongly encouraged to look at CDCs STI Treatment Guidelines for further diagnostic considerations.
Dr Scott Gottlieb: Highly Likely Virus Will Return In The Fall
But a virus can’t break into just any cell in the body. Instead, one of its proteins will bind to another protein akin to a key fitting into a lock which then allows the virus to hijack certain cells. With this outbreak, the coronavirus’ so-called spike protein primarily fits “locks” that are present on lung cells, which is why COVID-19, the disease it causes, is mainly a respiratory illness.
Once the invasion takes place, the cell in essence is transformed into a factory that churns out hundreds and hundreds of copies of the virus, based on instructions encoded in its genetic material RNA, or ribonucleic acid, in the case of the coronavirus.
“It basically acts like a thief inside the cell, stealing all of the cellular machinery and repurposing those machines to make more of the virus,” Glaunsinger said.
The human body has evolved defense systems to protect against these kinds of infections.
First, cells have a built-in alarm system to detect viral invaders. The presence of an intruder triggers what’s known as an innate immune response, which can involve the host cell releasing a protein that tries to interfere with the virus’ replication or can involve the immune system trying to shut down the compromised cells.
But sometimes, these defense mechanisms aren’t enough.
“At that point, the virus has already been amplifying, it has already been transmitted from that person to other people, and nobody feels terrible yet,” she said.
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Circumventing Your Bodys Immune System
Viruses have an exceptional ability to circumvent your bodys immune system and cause illness. Scientists have long believed that if we could just understand the tactics the viruses use when they attack the immune system that we could also find a way to stop them. This is exactly what researchers from the Department of Biomedicine at Aarhus University, Denmark set out to discover.
The team had already carried out years of research into the immune systems ability to fight diseases caused by the herpes virus, influenza viruses and, most recently, the SARS-CoV2 virus, the coronavirus responsible for the COVID-19 infection.
Their new study could be the breakthrough weve all been waiting for.
Do Condoms Help Prevent The Spread Of Genital Herpes
Yes. To prevent transmission of herpes, we recommend that condoms be used 100% of the time. Many patients will shed the virus and be contagious when they dont have symptoms. Studies have shown that asymptomatic shedding occurs between 1% and 3% of the time in patients with HSV II genital infections. Many new herpes infections occur from partners who are shedding the virus asymptomatically, so condoms are highly recommended.
Condoms may not be an attractive option for monogamous couples or for couples who desire to become pregnant. Couples may opt to have serological tests to determine if either partner has an asymptomatic infection. In close monogamous relationships, the risks of transmission can be weighed against other relationship issues, such as intimacy and pregnancy.
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Antiviral Method Against Herpes Paves The Way For Combating Incurable Viral Infections
- Lund University
- Researchers have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted. The treatment consists of new molecules that penetrate the protein shell of the virus and prevent genes from leaving the virus to infect the cell. It does not lead to resistance and acts independently of mutations in the genome of the virus.
Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted. The treatment consists of new molecules that penetrate the protein shell of the virus and prevent genes from leaving the virus to infect the cell. It does not lead to resistance and acts independently of mutations in the genome of the virus. The results are published in the journal PLOS Pathogens.
The virus consists of a thin protein shell, a capsid, and inside it lies its genome, the genes. Alex Evilevitch has previously discovered that the herpes virus has high internal pressure because it is tightly packed with genetic material.
Since all types of herpes viruses have similar structure and physical properties, this antiviral treatment works on all types of viruses within the herpes family.
Does A Cold Sore On My Mouth Mean I Have Genital Herpes
No, a cold sore on your mouth usually means you have herpes simplex virus type 1 . You can get HSV-1 by kissing someone or sharing utensils, towels, razors, or lipstick with someone who has HSV-1.
HSV-1 cannot turn into HSV-2 , but you can get a cold sore on your mouth from HSV-2 if you give oral sex to someone with HSV-2. Cold sores caused by HSV-1 or HSV-2 are contagious. You can spread it to other people or other parts of your body if you touch an open sore and then touch another part of your body. That means if you have a cold sore and give oral sex to someone, that person will get the herpes virus on his or her genitals.
Avoid touching your cold sore as much as possible. If you touch your cold sore, wash your hands right away to avoid spreading the infection to other parts of your body or other people.
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Signs And Symptoms Of Herpes
Both kinds of herpes cause outbreaks of painful sores on the skin. Symptoms of herpes include:
Oral herpes sores
Genital herpes sores
The sores that appear in the genital area can come from HSV-1 or HSV-2. Like the sores on the mouth, they start as painful blisters, then dry up and heal over time.
Although they usually show up around the mouth or genitals, herpes sores can appear anywhere on the body.
Not all people who have herpes have frequent outbreaks. Some people might have a single outbreak then never show symptoms again. The virus may stay dormant in their body.
Scientists Find Achilles Heel Of Coronavirus Herpes And Influenza
Most people who get a virus later recover with no long-term problems. This is true even for COVID-19, the coronavirus that has spread across the entire globe and stolen countless lives.
But not everyones immune system is capable of fighting back and winning.
New research has discovered how viruses gain a foothold in the body and what could be the Achilles heel that allows us to defeat coronavirus for good.
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Can Genital Herpes Kill You
If you suffer from genital herpes you are most likely emotionally disturbed because this disease, in addition to the physical damage to the genitals, affects our affective area.
However, you should be aware that recent research about the association between genital herpes and HIV has shown that patients with genital herpes are more likely to get HIV than people without it.
This treatment to kill herpes virus will allow you to get rid of herpes fast.
Herpes Myths To Stop Freaking Out About
A surprising number of people you know probably have herpes.
Shocked? You shouldnt be, since the virus is very common. According to the World Health Organization, 3.7 billion people under age 50 have herpes simplex virus type 1 thats 67 percent of the global population in that age bracket. Another 417 million people between ages 15 and 49 worldwide have herpes simplex virus type 2 .
Many people consider HSV-1 more benign, but it turns out theres not much difference between the two types of virus. While its true that HSV-2 is a sexually transmitted disease and can cause genital sores or blisters, type 1 can do the same thing.
One big misconception is that cold sores are caused by HSV-1 and genital herpes are always type 2, but thats not always the case, says Sarah Vensel, a physician assistant in San Francisco. Cold sores are so common theyve been normalized at this point. But genital herpes is sometimes the exact same virus just in a different location.
Not only is herpes incredibly common its also totally manageable. Allow us to set your mind at ease and debunk three widespread herpes myths:
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Can Immune System Kill Herpes Virus
The immune system cannot eliminate the virus of our body. For that reason it is necessary a treatment to fight it.
If this question had an affirmative answer, the question: does herpes cure itself?, should also have one, because the immune system would eliminate the virus without the need for treatment.
Slicing And Dicing On A Molecular Level: Meganuclease And Crispr
Wilder: The article you published with your colleagues discusses the cutting enzymeits called meganuclease?
Jerome: Thats right.
Wilder: What exactly is meganuclease? Has it been used in any other kind of research, or is it something your team is pioneering?
Jerome: Meganucleases are essentially a fancy name for the molecular scissors that we use to locate the virus. They recognize a specific type of DNAin this case, 20 letters of DNA.The letters have to be in the perfect order the perfect combination. If the meganuclease sees the 20 letters in exactly the right order, it will make a cut in the DNA. Thats what we use to destroy the herpes.
Meganucleases have been around a very long time they actually evolved in yeast. Weve come to appreciate their biology over the last 20 years or so, and theyve been used for gene editing purposes for over a decade. Thats why we got into this.
Part of the reason you dont hear about meganucleases now is that, to some degree, theyve been sort of replaced by the CRISPR system. One of the things that we deal with, with any type of molecular scissorswhether its CRISPR or the meganucleases: You have to change it so that it will recognize the 20 letters in the right order.
The proteins that evolve naturally in yeast dont have anything to do with herpes. So we need to change the letters that theyre looking for. For a meganuclease, its quite a difficult process that can take months. For CRISPR, you can actually do that overnight.
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The Science Behind The Hunt For A Herpes Cure
Wilder: I read that you started thinking up a possible cure for herpes around 10 years ago.
Jerome: Well, that was when I first became aware of what today has become an area of research that we call gene editing. A lot of your readers may have heard of a particular type of gene editing protein called CRISPR. Its made a lot of news over the past two or three years — including the lay press, not just the scientific literature. But, actually, CRISPR is only one type of protein for gene editing. There are other types, as well.
When I first became aware of that, I realized that gene editing proteins have the unique capability of very specifically looking for the DNAthe stuff of lifeof, in this case, a virus, and ignore everything else. I realized that gene editing proteins could actually find an infectionwhether it was HIV, herpes, or hepatitis Bdestroy that DNA, and leave the rest of the body alone.
Remember that these sleeping viruses that I mentioned are long-lived forms of DNA within the body. So if we could destroy the viruses in a very selective manner, we might have a possibility to think about cure.
Wilder: As you mentioned, the current drugs that are prescribed dont get rid of the latent virus. What is it about this virus that makes it so challenging to eliminate?
Jerome: Once the virus goes to sleep in the nerve cells, it coils itself up into a little circle. In a lot of ways, that little circle looks a lot like our own DNA.