Monday, September 19, 2022

Why Herpes Virus Cannot Be Cured

How Does Herpes Simplex Spread

It Might Be Good to Have Herpes | Trained Immunity

Herpes spreads through close contact with a person who has the infection. The virus can be found in skin and saliva. If you have herpes simplex, you are most likely to pass the virus to another person when you have sores. But you can infect someone else even if you have no symptoms. Healthcare providers call this asymptomatic viral shedding.

People may get HSV-1 through

  • Touching a persons skin near the mouth.
  • Sharing food utensils, lip balm or razors.
  • If you receive oral sex from someone who has a cold sore, it may spread a herpes infection to your genitals.

People may get HSV-2 through

  • Oral sex with someone whos infected.
  • Skin-to-skin contact without ejaculation.
  • Touching open sores, including while breastfeeding.
  • Childbirth by a mother or gestational parent who has an active infection.

You cant get genital herpes from objects like toilet seats. But you could pass genital herpes through shared sex toys.

How Can You Avoid Getting Herpes

âTo prevent getting a herpes infection, definitely avoid contact with any active oral or genital lesions,â says Jeffy. âFor oral herpes, you should avoid sharing objects that may have saliva on them such as silverware. Condoms can reduce the chance of getting genital herpes.â

  • Using condoms during symptom-free phases
  • Limiting your number of sexual partners
  • Talking openly and honestly with your partner about the virus

If youâve had several genital herpes outbreaks, antiviral medication may be an option.

âHerpes can be managed optimally with antiviral oral medications,â says Robin Evans, MD, and board-certified dermatologist at Southern CT Dermatology Stamford. âThe pills can be taken at the first signs of an outbreak, ideally with the prodromal tingling sensation that precedes the blistering eruption. If taken at this time, an outbreak may be prevented.â

Although there isnât a herpes vaccine, there are three FDA-approved antiviral medications available to treat genital herpes symptoms:

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What Characteristics Identify The Hsv Eraser Program

The second idea is based on the fact we must strengthen our immune system so that it destroys the virus, once the protein that hides it is separated.

Our program carries out these ideas in a two-stage process that lasts approximately three weeks.

The first stage lasts 10 days and during it, the patient must consume specific doses of vitamins, supplements and organic compounds that separate the ICP47 protein from the infected cells so that the immune system can destroy the virus.

The second stage of the treatment starts from the tenth day and lasts from 11 to 13 days.

During this stage, the patient must consume specific doses of vitamins and food supplements that strengthen the immune system so that it is able to destroy the virus.

When the treatment is finished, the patient will be free of herpes forever.

This treatment is completely natural and free from harmful side effects.

The identity of our treatment is determined by the compounds to be consumed by the patient, the time when the patient should consume them and the doses to be used.

The combination of these three factors is the key to the effectiveness of HSV Eraser.

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The Science Behind The Hunt For A Herpes Cure

Wilder: I read that you started thinking up a possible cure for herpes around 10 years ago.

Jerome: Well, that was when I first became aware of what today has become an area of research that we call gene editing. A lot of your readers may have heard of a particular type of gene editing protein called CRISPR. Its made a lot of news over the past two or three years — including the lay press, not just the scientific literature. But, actually, CRISPR is only one type of protein for gene editing. There are other types, as well.

When I first became aware of that, I realized that gene editing proteins have the unique capability of very specifically looking for the DNAthe stuff of lifeof, in this case, a virus, and ignore everything else. I realized that gene editing proteins could actually find an infectionwhether it was HIV, herpes, or hepatitis Bdestroy that DNA, and leave the rest of the body alone.

Remember that these sleeping viruses that I mentioned are long-lived forms of DNA within the body. So if we could destroy the viruses in a very selective manner, we might have a possibility to think about cure.

Wilder: As you mentioned, the current drugs that are prescribed dont get rid of the latent virus. What is it about this virus that makes it so challenging to eliminate?

Jerome: Once the virus goes to sleep in the nerve cells, it coils itself up into a little circle. In a lot of ways, that little circle looks a lot like our own DNA.

Is Genital Herpes Infection Related To Hiv

How dormant herpes springs back to life

Herpes and HIV are caused by different viruses. But patients infected with these viruses are more likely to transmit either disease to their sexual partners. Patients with herpes are more vulnerable to HIV infection. People newly diagnosed with herpes should be tested for HIV infection and other sexually transmitted infections.

Patients who are infected with both herpes and HIV also may have a higher concentration of HIV viruses in their body because of the interaction between the herpes virus and the HIV virus. When HIV damages a persons immune system, the person may be more likely to shed herpes simplex virus asymptomatically.

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Can You Get Rid Of Herpes Yourself

As mentioned above, the herpes virus cannot be completely cured but it can be treated. And while there is no way to treat the virus yourself from home, the blisters can sometimes heal and clear up on their own without treatment.

If you are experiencing discomfort from herpes sores, and you have been diagnosed with herpes by your doctor, according to the NHS there are a handful of ways to help relieve herpes symptoms, these include:

  • Keep the area clean to avoid the blisters becoming infected
  • Apply petroleum jelly or painkilling cream to ease any pain when using the toilet
  • Avoid wearing tight clothing that could irritate the blisters
  • Dont apply ice directly to the blisters

I Hope That This Study Changes The Dialogue Around Herpes Research And Opens Up The Idea That We Can Start Thinking About Cure Rather Than Just Control Of The Virus

â Dr. Keith Jerome, Fred Hutchinson Cancer Research Center

Whereas most research on herpes has focused on suppressing the recurrence of painful symptoms, the Fred Hutch gene therapy work addresses the root cause of reactivation: the presence of latent virus in infected nerve cells.

âI hope that this study changes the dialogue around herpes research and opens up the idea that we can start thinking about cure, rather than just control of the virus,â Jerome said.

It will still take a long time before these experiments lead to the first human trials of gene therapy to cure herpes. Jerome estimates that will be at least three years away.

Herpes simplex viruses afflict billions of human beings around the globe. According to the World Health Organization, two-thirds of the world population under the age of 50 carry herpes simplex virus type 1, or HSV-1, which primarily causes cold sores, while 491 million people aged 15-49 are infected with closely related HSV-2, which is the cause of sexually transmitted genital herpes.

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Genital Herpes And Pregnancy

It is important to avoid contracting herpes during pregnancy. A first episode during pregnancy can create a greater risk of transmission to a newborn.

Fortunately, it is rare for women with genital herpes to infect their babies. If you know that you have genital herpes before becoming pregnant, your physician will monitor your condition throughout your pregnancy. If you have an active outbreak at the time of delivery, a C-section may be recommended. Depending on individual diagnosis, though, the American Congress of Obstetricians and Gynecologists endorses suppressive therapy to reduce the frequency of C-section.

Is There A Cure For Herpes Simplex

Herpes virus treatment

There is no cure for herpes simplex. Once you have the virus, its a lifelong infection.

What is the outlook for people with herpes simplex?

For many people, the first herpes outbreak is the most severe. Many outbreaks are less frequent and milder after the first year of infection. Some people may have only one outbreak and never have another again.

Herpes infection doesnt usually pose a serious health risk. The risk of a health complication due to herpes is higher in infants and if you have HIV/AIDS, cancer or an organ transplant.

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Why Viral Infections Are So Hard To Cure And How Antivirals Like Covid

Australian doctors recently added another drug to their repertoire of COVID-19 treatments one that stimulates the bodyâs immune system to intercept and destroy the virus.

The drug, called sotrovimab, is an addition to a handful of green-lit treatments, most of which help calm inflammation caused by the immune systemâs overreaction to the virus.

But only one approved drug, remdesivir, interrupts a virusâs rampage within our cells, where millions of copies of the virus are made and sent out to infect more cells and people.

So why is it so hard to break the lifecycle of viruses such as SARS-CoV-2, which causes COVID-19 disease?

In a way, COVID-19 is a disease of two stages, says Raymond Schinazi, who develops antiviral drugs at Emory University.

During the first stage of the disease, the virus makes copies of itself in your body, often without producing symptoms.

In the second, your bodyâs immune system kicks in. For some people, this progresses to severe disease as their immune system attacks organs and causes inflammation.

âWe have drugs that work at the late stage, and weâre trying to develop drugs that work early, that can be given on an outpatient basis,â Professor Schinazi says.

The idea of treating the early stage of the infection with antivirals is to stop people from progressing to the point where severe disease sets in.

Todays Reality: Herpes In The Us

Terri Wilder: Thanks for being here with me today, Dr. Jerome. My first question is: Why is herpes simplex virus a public health problem?

Keith Jerome: Well, herpes is unique. Its part of a relatively small family of viruses that cause infection for life.Once the virus gets into a person, it finds a particular place it likes to essentially fall asleepwe call it latency. But for herpes simplex, it goes to neurons within the body called nerve cells. The virus could basically go there to sleep, where the body doesnt notice it and the normal medications that we have today dont notice it. But every once in a while, the virus can wake up and then travel back out from those nerve cells. Thats what causes the ulcerations or lesions that people get.

And so, were very interested in answering: Is there something that we can provide to help people not just control the infection, but actually get rid of it?

Wilder: Can you speak to the link between herpes and HIV?

Jerome: Absolutely. Having herpes simplex virus raises a persons risk of acquiring HIV about twofold. Obviously, there are other risk factors for HIV, but on a population-wide basis, particularly in areas where the incidence of HIV infection is very high, along with a high level of herpes simplex virusfor example, in parts of sub-Saharan Africawe think that almost half of all the HIV cases that exist can actually be traced back to a pre-existing herpes simplex virus infection.

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How Herpes Is Treated

There is no cure for herpes.

  • The health care provider may prescribe antiviral medicine to help speed up the healing process. It also shortens the time when the virus can spread from the herpes sores.
  • Pain may be treated with medicine such as Tylenol or Motrin or by applying an ice pack wrapped in a towel to the affected area.
  • If sores are in the mouth, avoid foods high in acid, like citrus fruits and juices.
  • The infected area should be kept clean and dry.
  • Wash hands often and avoid touching the sores to prevent spreading the virus.
  • It is important to stay healthy by getting enough rest, having proper nutrition and exercise and managing stress well.

How Do You Treat Herpes

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Although there is no cure for herpes and symptoms can sometimes clear up on their own, its important to seek treatment to reduce both the severity and frequency of the infection.

In saying that, while treatment for herpes cannot completely cure the virus, it can help in reducing the symptoms of herpes and reduce the likelihood of it spreading between sexual partners. Similar to how the signs and symptoms of oral and genital herpes can differ, the treatments for each tend to vary.

See also:What is Herpes? How to Deal With a Herpes Diagnosis

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No Cure: Vaccine Needed

There is no cure for herpes. Antiviral medications, such as acyclovir, famciclovir, and valacyclovir, can help to reduce the severity and frequency of symptoms but cannot cure the infection.

Better awareness, improved access to antiviral medications and heightened HIV prevention efforts for those with genital HSV symptoms are needed globally. In addition, development of better treatment and prevention interventions is needed, particularlyHSV vaccines.

A vaccine against HSV infection would not only help to promote and protect the health and well-being of millions of people, particularly women, worldwide it could also potentially have an impact on slowing the spread of HIV, if developedand provided alongside other HIV prevention strategies says Dr Meg Doherty, Director of the WHO Department of Global HIV, Hepatitis, and STI Programmes.

What Are The Symptoms Of Herpes Simplex

Many people with the infection never experience any herpes symptoms. If you do notice symptoms, youll experience them differently depending on whether youre having your first herpes outbreak or a repeat outbreak. Recurring symptoms are usually milder than the first outbreak. Symptoms dont last as long with later outbreaks. Some people may only have one or two outbreaks during their lifetime. Others may have as many as four or five outbreaks a year.

People who do have herpes symptoms may experience:

  • Cold sores around their lips, mouth or tongue. They may look crusty or like fluid-filled blisters.
  • Tingling, itching or burning.
  • Pain while urinating.

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Can Herpes Go Away Forever

While the signs and symptoms associated with both types of herpes can come and go, the virus stays in the body and there is no cure.

With that said, the treatments available can help herpes outbreaks become shorter and less frequent. There are also medications available that can lower the risk of spreading the infection to others.

One of the best ways to reduce your risk of contracting an STD is with regular screening. This can be done by taking a trip to your doctors office or from the comfort of your own home with an at-home lab test.

LetsGetCheckeds at-home Herpes Test can detect herpes simplex antibodies for either HSV-1 or HSV-2. Online results will be available within 5 days and our dedicated medical team will be there to offer a helping hand should you have any questions.

You should consider taking the test if:

  • You become sexually active
  • You have had unprotected sex
  • You are experiencing symptoms of a sexually transmitted infection
  • You are entering into a new sexual relationship
  • You have received a notification from a previous partner that they are infected

What Are The Symptoms Of Herpes

Herpes Simplex Virus

“HSV-1 primarily causes oral herpes and is transmitted by oral-to-oral contact,” says Jeffy. “HSV-2 generally causes genital herpes and is sexually transmitted.”

Both HSV-1 and HSV-2 are highly contagious and can be spread even if there are no visible signs of the virus.

HSV-1

HSV-1 or oral herpes is characterized by blister-like sores on the lips and mouth and is spread via kissing, sharing objects , or practicing oral sex with someone who has the virus.

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Could Peptoids Be A Wide

Additional experiments are now underway to confirm the mouse findings. In addition, the peptoids could be effective against HSV-1 drug-resistant strains. The antimicrobial molecules could have a host of applications. Work is ongoing at Stanford to explore their impact on ear and lung infections. Dr. Barrons team has sent peptoid samples to experts in other labs to test against a range of viruses. There have been promising results in lab dish studies against influenza, the cold virus, and hepatitis B and C.

In their in vitro studies, a team found that two of the peptoids were the most potent antivirals ever identified against MERS and older SARS coronaviruses, Dr. Barron says.

Other labs are testing the peptoids as anti-fungals for airways, the gut, and as anti-infective coatings for contact lenses, catheters, and implanted hip and knee joints. The researchers are studying how these broad-spectrum compounds work. The study notes that such antivirals seem to pierce and break up the viral envelope and also bind to the virus DNA.

That multipronged mechanism has the advantage of inactivating the virus. Standard antivirals slow replication but still allow viruses to infect cells. It also makes it less likely that pathogens could develop resistance.

The team presented their findings at the American Chemical Society virtual meeting ACS Fall 2021.

South West News Service writer Mark Waghorn contributed to this report. This article was first published August 27, 2021.

Scientists Find New Understanding Of Why Herpes Can’t Be Cured

Category: Herpes

A study published in the Journal of Leukocyte Biology reveals that the immune system may have greater trouble controlling the herpes group cytomegalovirus and preventing breakouts when it has to combat other viral or bacterial infections as well.

The researchers looked at a group of mice with latent herpes, and they observed that when the mice had a bacterial infection, their T-cells, or the “brakes”, which control the CMV outbreaks, decreased in number.

“Because almost all people are infected by one or more herpes family viruses during their lifetime, the potential impact of these findings are significant,” said research author Charles H. Cook, M.D., FACS, FCCM, director of surgical critical care at The Ohio State University College of Medicine. “We hope that by understanding how these latent viral infections are controlled that we can prevent reactivation events and improve people’s lives.”

Genital herpes statistics and transmissionAccording to the Centers for Disease Control and Prevention , nearly one out of every 16 people from 14 to 49 years old has genital herpes, which can be detected with herpes 2 testing.

The CDC notes that many people who have herpes don’t have any symptoms of the infection or don’t know that they have it. When someone does have a herpes “outbreak” they usually get blisters around the genitals or mouth, which can take up to a month to heal.

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