A Cure For Herpes There Is Progress To Report
It takes a persistent scientist to stop a persistent virus.
A decade ago, Fred Hutchinson Cancer Research Center virologist Dr. Keith Jerome began exploring the idea that lifelong infections with herpes viruses might be cured by using the DNA-cutting tools of gene therapy.
Initial research showed these techniques could knock out small quantities of latent virus, and the work of improving the results fell to Jeromeâs senior staff scientist, Dr. Martine Aubert. Five years ago, the team reported they had damaged the genes of 2%-4% of herpes virus in infected mice. Aubertâs work was an important proof of principle, but far short of a cure.
Nevertheless, she persisted.
On Aug. 18, the team led by Jerome and Aubert published a paper in Nature Communications showing that, through a series of incremental improvements on their original method, they had destroyed up to 95% of herpes virus lurking in certain nerve clusters of mice.
âThis is the first time that anybody has been able to go in and actually eliminate most of herpes in a body,â said Jerome, who is also spearheading research at Fred Hutch and the University of Washington on COVID-19. âIt is a completely different approach to herpes therapy than anybodyâs ever had before.â
Natural Treatment For Herpes Simplex 2
The first step should be preventive, to not contract the virus. This can be achieved by having protected sex, by not having sex with people whom one doesnt know for a long time as that would make the symptoms of herpes obvious and to maintain impeccable hygiene.
Herpes is A Relationship Killer!
Avoiding nonsexual contact is not always possible so staying off all kinds of physical contact with people who seem sick is advisable. Some symptoms of herpes simplex 2 infection may look like other ailments.
Common cold or flu and other not so harmful medical conditions can cause symptoms similar to those associated with herpes. Spotting these symptoms should be the red flag to avoid contact. While handshakes usually dont spread the herpes simplex 2, a simple peck on the cheek or hugging for a while with skin to skin contact, at the neck or around the facial region, can cause the spread of herpes simplex viruses. The fact that herpes simplex 2 virus causes genital herpes doesnt necessarily mean the virus only lives in the genital area.
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There is no traditional medicine that can cure genital herpes. Creams cannot eliminate herpes simplex 2 virus. You must resort to natural remedies, which may or may not work. Alternatively, you should opt for a proven cure that has worked for others. Herpes Cure Secrets is a proven remedy and can eliminate herpes simplex 2 virus.
So, what are you waiting for The Best Herpes Cure?
Genital Herpes During Pregnancy
Prevention of neonatal herpes depends both on preventing acquisition of genital herpes during late pregnancy and avoiding exposure of the neonate to herpetic lesions and viral shedding during delivery. Mothers of newborns who acquire neonatal herpes often lack histories of clinically evident genital herpes . The risk for transmission to the neonate from an infected mother is high among women who acquire genital herpes near the time of delivery and low among women with prenatal histories of recurrent herpes or who acquire genital herpes during the first half of pregnancy . Women who acquire HSV in the second half of pregnancy should be managed in consultation with maternal-fetal medicine and infectious disease specialists.
All pregnant women should be asked whether they have a history of genital herpes or genital symptoms concerning for HSV infection. At the onset of labor, all women should be questioned thoroughly about symptoms of genital herpes, including prodromal symptoms , and all women should be examined thoroughly for herpetic lesions. Women without symptoms or signs of genital herpes or its prodrome can deliver vaginally. Although cesarean delivery does not eliminate the risk for HSV transmission to the neonate , women with recurrent genital herpetic lesions at the onset of labor should have a cesarean delivery to reduce the risk for neonatal HSV infection.
Acyclovir 400 mg orally 3 times/dayORValacyclovir 500 mg orally 2 times/day
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How Do Dermatologists Treat Herpes Simplex
There is no cure for herpes simplex. The good news is that sores often clear without treatment. Many people choose to treat herpes simplex because treatment can relieve symptoms and shorten an outbreak.
Most people are treated with an antiviral medicine. An antiviral cream or ointment can relieve the burning, itching, or tingling. An antiviral medicine that is oral or intravenous can shorten an outbreak of herpes.
Prescription antiviral medicines approved for the treatment of both types of herpes simplex include:
Taken daily, these medicines can lessen the severity and frequency of outbreaks. They also can help prevent infected people from spreading the virus.
How Do You Get Genital Herpes
Genital herpes is a type of sexually transmitted disease caused mostly by HSV-2. Although HSV-1 can cause herpes rash in the genital area, it is less frequent compared with HSV-2. HSV-1 spreads by skin-to-skin contact, whereas HSV-2 spreads by sexual contact. Genital herpes rash is present on or around the genitals . When rash is in or on around the lips, mouth and throat, it is called oral herpes.
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How Long Do Sores From Herpes Simplex Last
If youre infected with HSV-1, commonly known as oral herpes, you may notice tingling or burning around your mouth in the days before a cold sore appears. These blisters break open and ooze fluid before forming a crust. Usually, sores last for seven to 10 days.
If youre infected with HSV-2, commonly known as genital herpes, your first outbreak may last between two to four weeks. Recurrent outbreaks usually last between three to seven days.
Treatment For Oral Herpes
The antiviral medications available in pill form have been specifically developed for the treatment of genital herpes. However, it is not uncommon for healthcare providers to prescribe the antiviral drugs to those who have frequent or severe outbreaks of oral herpes.
A recent study found valacyclovir to be effective for treating oral herpes in a one-day treatment of 2 grams taken at the first sign of a cold sore, and then again about 12 hours later.
There are two topical antiviral medications prescribed for the treatment of oral HSV symptoms: acyclovir ointment and penciclovir cream. Both work to speed up the healing process and reduce the viral activity. These topical drugs are put directly on the lesions themselves, but can also be used at the onset of prodrome.
Other topical treatments for oral herpes are available over-the-counter , but are not antiviral compounds like acyclovir and penciclovir. Some also contain ingredients that numb the area and induce temporary relief from the discomfort of an outbreak. Unfortunately, some OTC treatments may actually delay the healing time of symptoms because they can further irritate the area with repeated applications. There is only one OTC FDA-approved cream, called Abreva®, which has been clinically proven to help speed the healing process.
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How Does Genital Herpes Spread
Herpes can be spread when an infected person has lesions blisters and open sores on their body or when you do not have any symptoms. Taking antiviral medicine can help you reduce the risk of spreading genital herpes to your sexual partners. You can also:
- Inform your sexual partner that you have genital herpes.
- Use a condom every time you have sex.
- Refrain from having sex when you have symptoms.
- Abstain from performing oral sex if you have blisters or open sores around your mouth.
Can I Be Treated To Prevent Genital Herpes Transmission To My Partner
Yes. A large study showed that if one partner has herpes and the other partner is uninfected, treating the infected partner with suppressive therapy can prevent transmission of symptomatic herpes in over 90% of cases. This is an option for couples who are interested in having unprotected sex or who are planning to become pregnant.
If you are entering into a new relationship and are aware that you have herpes simplex infection, you owe it to your partner to notify them before having sex.
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How Common Is Genital Herpes
According to the Centers for Disease Control and Prevention, approximately 40 million to 50 million adults in the United States have genital herpes. HSV II infection is more common in women and in people who have had more than five sexual partners. Most people with HSV II do not know they have it, because it does not always cause symptoms.
Is There Any Resistance To Genital Herpes Medication
Resistance to drugs that treat genital herpes even after 20 years of use is very rare. Herpes medications may not work as well in patients who are very immunosuppressed and have been treated with these drugs for a long time. Each individuals response to treatment may vary. In some cases, patients may need more drugs to suppress their viral outbreaks than others.
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Approaches To Vaccine Development
Although there are no currently available vaccines for herpes simplex 1 and 2, there are various candidates in both the pre-clinical and the clinical phases currently in development. Vaccines are being developed with two broad focuses: preventative and therapeutic, some with a dual use. Preventative vaccines are focused on the prevention of primary infection in a seronegative subject. Therapeutic vaccines aim to prevent HSV reactivation, decrease the number of recurrences, or to reduce the severity or duration of clinical symptoms . With regard to vaccine development, given our knowledge of the immunology surrounding HSV, it seems that an effective vaccine would likely stimulate not only humoral responses, but also cell-mediated responses. Different vaccine subtypes have their unique advantages and disadvantages, discussed further in the next section.
Recombinant vaccines are usually composed of proteins that are not strong immunoactivators. Therefore, they require adjuvants to stimulate the innate immune system. This leads to the humoral response and proper inoculation. They are not needed for live-attenuated viruses. Different constituents can enhance and target different facets of the immune response. It is important to focus on the adjuvants in each vaccine trial and evaluate their role in eliciting a lasting humoral and cell-mediated response .
‘i Hope That This Study Changes The Dialogue Around Herpes Research And Opens Up The Idea That We Can Start Thinking About Cure Rather Than Just Control Of The Virus’
â Dr. Keith Jerome, Fred Hutchinson Cancer Research Center
Whereas most research on herpes has focused on suppressing the recurrence of painful symptoms, the Fred Hutch gene therapy work addresses the root cause of reactivation: the presence of latent virus in infected nerve cells.
âI hope that this study changes the dialogue around herpes research and opens up the idea that we can start thinking about cure, rather than just control of the virus,â Jerome said.
It will still take a long time before these experiments lead to the first human trials of gene therapy to cure herpes. Jerome estimates that will be at least three years away.
Herpes simplex viruses afflict billions of human beings around the globe. According to the World Health Organization, two-thirds of the world population under the age of 50 carry herpes simplex virus type 1, or HSV-1, which primarily causes cold sores, while 491 million people aged 15-49 are infected with closely related HSV-2, which is the cause of sexually transmitted genital herpes.
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Herpes Simplex Treatment And Management
Herpes simplex infections can’t be cured, but treatments are available to reduce the number and length of outbreaks. The risk of transmitting the infection to others is also reduced.
Daily antiviral medications, such as acyclovir, valacyclovir, and famciclovir, may be prescribed. During an outbreak, self-care strategies can also help manage pain and discomfort.
For an oral herpes outbreak featuring cold sores or blisters around the mouth, do the following:
- Clean the affected area and pat dry
- Use over-the-counter pain relievers or ointments with ingredients such as benzocaine or lidocaine
- Apply OTC antiviral cold sore medication to the lesions to help them heal quicker
- Use petroleum jelly to keep skin from drying out or cracking
- Avoid acidic, spicy, or salty foods that may irritate your lesions
Self-care for a genital herpes outbreak may include:
- Use OTC pain relievers or cool compresses to help manage pain
- Wash affected area with mild soap and gently dry
- Wear loose fitting, cotton underwear
How Painful Is Herpes Simplex
Some people experience very mild genital herpes symptoms or no symptoms at all. Frequently, people infected with the virus don’t even know they have it. However, when it causes symptoms, it can be described as extremely painful. This is especially true for the first outbreak, which is often the worst. Outbreaks are described as aches or pains in or around the genital area or burning, pain, or difficulty urinating. Some people experience discharge from the or .
Oral herpes lesions usually cause tingling and burning just prior to the breakout of the blisters. The blisters themselves can also be painful.
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Can I Still Have Sex If I Have Herpes
If you have herpes, you should talk to your sex partner about their risk. Using condoms may help lower this risk but it will not get rid of the risk completely. Having sores or other symptoms of herpes can increase your risk of spreading the disease. Even if you do not have any symptoms, you can still infect your sex partners.
You may have concerns about how genital herpes will impact your health, sex life, and relationships. While herpes is not curable, it is important to know that it is manageable with medicine. Daily suppressive therapy can lower your risk of spreading the virus to others. Talk to a healthcare provider about your concerns and treatment options.
A genital herpes diagnosis may affect how you will feel about current or future sexual relationships. Knowing how to talk to sexual partners about STDs is important.
The Virus And Pathogenesis
HSV is a double-stranded DNA virus that may enter the host through abraded skin or intact mucous membranes.1 Epithelial cells are the initial targets. Once infected, these cells die, releasing clear fluid intradermally to form vesicles and merging with other cells to create multinucleated giant cells.
Retrograde transport through adjacent neural tissue to sensory ganglia leads to lifelong latent infection.1 Reactivation of the virus is triggered by local or systemic stimuli such as immunodeficiency, trauma, fever, menstruation, ultraviolet light and sexual intercourse.13 Although emotional stress is assumed to trigger HSV recurrence, recent research fails to show a definite causative role.4 Once reactivated, the virus is transported by the neuron back to the epithelium, where more replication occurs, and another outbreak ensues.
HSV exists as two separate types, labeled 1 and 2, which have affinities for different body sites.2 Ninety percent of infections caused by HSV-2 are genital, and 90 percent of those caused by HSV-1 are oral the reason for this division is unknown.5 In addition, oral HSV-1 infection recurs more frequently than oral HSV-2, and genital HSV-2 recurs more often than genital HSV-1.
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Genital Herpes And Pregnancy
It is important to avoid contracting herpes during pregnancy. A first episode during pregnancy can create a greater risk of transmission to a newborn.
Fortunately, it is rare for women with genital herpes to infect their babies. If you know that you have genital herpes before becoming pregnant, your physician will monitor your condition throughout your pregnancy. If you have an active outbreak at the time of delivery, a C-section may be recommended. Depending on individual diagnosis, though, the American Congress of Obstetricians and Gynecologists endorses suppressive therapy to reduce the frequency of C-section.
What Does Genital Herpes Look Like
While some people with genital herpes will never have any symptoms, other people can develop symptoms within a few weeks of being infected.
Often, before the lesions appear, patients describe a prodrome, characterized by a tingling or burning sensation in the area where the lesions will develop that can be noticed during urination, along with itching or discomfort in the genital area.
You can also have the following symptoms:
- Blisters on the mouth or lips
- Fever, headache or pain in the joints
- Trouble urinating
The symptoms of genital herpes often go away and come back as recurring outbreaks. For most people, the first outbreak is the worst, and can last from two to three weeks. Future flare-ups are often less severe and do not last as long. Still, some people shed the virus regularly. The following triggers can make outbreaks more likely to occur:
- Viral or bacterial infections
- Menstrual periods
Recurrent genital herpes is most common in the first year after the initial infection and decreases as time goes on.
In many cases, anti-herpes medicine can help patients. When a person experiences a prodrome and suspects a recurrence is going to happen, they begin taking anti-herpes medications that lessen symptoms and shorten the time of the outbreak.
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Is There A Link Between Genital Herpes And Hiv
It is easier for a person with genital herpes to get or transmit HIV infection.
If a person with a herpes infection is genitally exposed to HIV, their risk of acquiring HIV is than someone without genital herpes. This is because genital herpes can cause breaks in the skin and make a person more vulnerable to HIV infection.
A person with HIV and genital herpes is more likely to transmit HIV to sex partners.