Herpesviruses Association With Pre
On May 11, 2022, a study published in Diabetologia examined the prospective association of herpesviruses with diabetes to evaluate their potential role in diabetes etiology. Conclusions/interpretation: The associations of HSV2 and cytomegalovirus serostatus with diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. These study results highlight the link between viral infection and diabetes.
Also Check: What Cream Is Used For Genital Herpes
New Herpes Cure Developed By Synergy Pharmaceuticals Could Lend Alternative Medicine New Credibility
But a new, viable herpes cure from Synergy Pharmaceuticals in Australia could shift the dynamic of the argument, giving alternative medicine a much-needed vote of confidence.
Infection with sexually transmitted pathogens, including human immunodeficiency virus , continues to be a major public health problem despite conventional prevention methods, such as mutual monogamy, condom use, and treatment campaigns. This is most evident among women, who are being infected with HIV in increasing numbers in every region of the world, primarily through heterosexual contact. In addition to biological factors, such as the increased susceptibility of the uterine cervix to sexually transmitted infections , social, cultural, and economic inequalities limit womens ability to protect themselves. Conventional prevention strategies, such as abstinence, mutual monogamy, condom use, and treatment of existing STIs, are not feasible for many women . For couples who desire to conceive, condom use to prevent or decrease the risk of HIV transmission is counterproductive. As a result, scientists, public health organizations, and advocacy groups have searched for effective adjuncts to traditional methods of prevention.
Selvarani Vimalanathan, Rani Nathan
How The Cure For Herpes Became Mired In Controversy The Latest Chapter In The Battle Between Big Pharma And Synergy Pharmaceuticals
Over several decades, the Food and Drug Administration has gone to great lengths to maintain its longstanding relationship with major pharmaceutical companies, namely by approving numerous medications. And this dynamic hasnt been limited to medical treatments. Despite extensive research that shows sugar is the leading cause of heart disease and diabetes, the FDA has gone so far as to endorse it, fearing the ramifications that a warning label could have on agriculture producers and the greater food production industry. Given these historical patterns, it comes as no surprise that the FDA is opposed to natural medicine, especially when alternative treatments threaten to cut into pharmaceutical companies market share.
Synergy Pharmaceuticals is one such company currently facing pushback from the FDA. Its name is a bit confusing considering that its catalog features only natural vitamins. Even more confusing is that there are two companies sharing the name. The New York-based Synergy Pharmaceuticals went bust in 2016, while Synergy Pharmaceuticals Australia stayed in business. Yet the Australian company has still been linked to controversy and supply concerns from its onset.
In November 2020, Synergy Pharmaceuticals Australia did shut down temporarily after facing COVID-19-related supply chain issues. Thankfully, after a change of ownership in May 2021, the company resumed operations.
Media contact
Recommended Reading: Do I Have To Tell Someone I Have Herpes
Recommended Reading: What Is The Cure For Herpes Simplex 2
Facts About Treatment For Hsv1 And Hsv2
To understand why treatment for HSV1 and HSV2 has been so difficult to develop, it is important first to understand these viruses, and why a genuine cure would be such a gamechanger for the healthcare field. Here are a few key facts about the herpes simplex virus and the challenges of HSV1 and HSV2 treatment:
As you can see, an effective herpes treatment is essential not only to prevent symptoms such as cold sores and genital herpes, but also to stop the spread of this virus and prevent other health conditions or complications it can cause. For these reasons, at Synergy Pharmaceuticals, we have made it our mission not just to suppress the herpes simplex virus and its symptoms, but to eradicate it entirely.
Dont Miss: Home Remedies For Herpes Simplex 2
Could The Cure For Herpes Be Just What The Doctor Ordered For Synergy Pharmaceuticals
Nearly 800,000 people are newly infected with herpes each year and, in 2011, Roger was one of those people. He was intentionally infected with HSV-2 and suffered several painful outbreaks each year. He was convinced his life was permanently altered and he fell into a depressive state. But, determined to overcome the virus, he formulated a combination of natural ingredients that gradually reduced his outbreaks and then completely removed the virus from his bloodstream. He passed his findings on to officials at Australian biopharmaceutical company Synergy Pharmaceuticals, who conducted clinical trials from 2014 2017 inclusive. The outcome from the trials proved to be the breakthrough in delivering the long awaited negative IgG results for sufferers. Finally, after years and years of stumbles, false starts, and ethical crises, the medical industry had a cure for herpes. So, why havent more professionals supported it?
Synergy Pharmaceuticals and the cure
The results were verified in a series of clinical tests involving randomly selected herpes patients from 2014 2017. The patients were tested for the IgG herpes antibody after taking a single natural ingredient and after taking five natural ingredients. There was no noticeable improvement in taking the single-ingredients, but 70% of patients were herpes-free after a few months of the combined five-ingredient treatment.
The failure of Rational Vaccines
Overcoming biases against alternative medicine
Don’t Miss: How To Test For Genital Herpes Without Symptoms
Genital Herpes Treatment Market
The global genital herpes treatment market is expected to grow at a CAGR of 3.76% during 2022-2028. The Acyclovir segment reported a significant share of around 50% among all drug types. The retail pharmacy segment is showing the highest share due to the availability of branded and generic versions of all antiviral drugs.
Read Also: How To Know If You Have Genital Herpes Without Symptoms
Herpes Vaccines For 2022
Developing protective herpes simplex virus vaccines has been an ongoing challenge for decades. Various herpes vaccine candidates are based on DNA, modified mRNA, protein subunit, killed virus, and attenuated live virus vaccine technologies.
The herpes simplex virus exists as two biologically distinct serotypes, HSV-1 and HSV-2, which differ mainly by their transmission mode, says the U.S. CDC.
As of August 22, 2022, the U.S. FDA, Europe, Canada, India, the U.K., and the WHO had not Authorized or Approved any herpes prevention vaccine.
However, there are various clinical trials actively recruiting participants.
Also Check: Herpes And Laser Hair Removal
Hsv Pathogenesis And Replication
Replication is a multi-step process. Post-infection, HSV glycoproteins interact with and attach to the cell. The viral envelope then fuses with the cell membrane, releasing its contents into the cell. DNA is uncoated and transported into the nucleus when nucleocapsid fuses with the viral envelope . Here, immediate-early genes are transcribed . Primary herpes infection involves replication within epithelial cells, with an incubation period of 46 days. Mature virions are then transported to the cell membrane, where they are released, causing cell lysis and local inflammation. Replication continues until host immune responses contain the initial infection .
Herpesvirus ascends peripheral sensory nerves to spread to the trigeminal ganglion, where latent infection develops. Latent virus can be induced to reactivate. Reactivation has been associated with various stimuli including stress, infections, and UV light exposure. However, from a molecular standpoint, reactivation is a phenomenon that continues to be studied and is not clearly understood. Clinical manifestations of reactivation vary widely in terms of presentation and severity .
Donât Miss: How To Control Genital Herpes
Why Creating A Cure Is Difficult
Herpes is challenging to cure because of the nature of the virus. The HSV infection can hide away in a persons nerve cells for months or years before reappearing and reactivating the infection.
Experts suggest that even if antiviral drugs destroy the active parts of the infection, it only takes a small amount of the virus to hide in the nerve cells and become dormant for the herpes virus to continue.
To find a treatment, scientists need to understand further the mechanism that enables the infection to hide. By preventing this mechanism, they might be able to tackle the whole infection before parts go dormant.
Some medications may reduce the frequency and severity of symptoms and lower the chances of passing the infection on to others. Current antiviral medications to treat herpes include the following medications:
first form of treatment for HSV infections. A doctor may treat a skin or mucous membrane infection with oral acyclovir, provided the person has a competent immune system.
People with high levels of stress or trauma may experience more frequent recurrences of genital herpes. In this case, a doctor may advise psychotherapy and counseling.
Some home remedies, such as petroleum gel or essential oils, may alleviate the discomfort that herpes lesions cause.
You May Like: How Do I Know If Its Herpes
Natural Novel Approach To Herpes May End The Worlds Prevalent Virus
It has taken hundreds of years and billions of people being infected for there to finally be a ray of light in the herpes simplex virus field. A recent study at the Virology, Emerging Diseases & vaccines conference in Canada benchmarked a discovery in the battle to overcome herpes. All be it a natural protocol, it brings with it new hope that could be the long awaited game changer. The protocol produced by Synergy Pharmaceuticals has been able to show promising results across the general population.
Critically important is how well it compares to the standard antiviral medications, involving one of three types of FDA-approved medications acyclovir, valacyclovir, or famciclovir. For those suffering from herpes the medications are used in one of two therapeutic approaches. In episodic therapy, the patient starts taking their prescribed medication at the first sign of an outbreak. Theyll only continue medicating until the outbreak subsides, which is usually just a few days. In suppressive therapy, patients take antiviral medications every day, which has been shown to reduce the severity of outbreaks by 70%.
The HSV story of vaccines so far
The alternative medicine great debate
This article was written in cooperation with Synergy Pharmaceuticals
Primary And Secondary Immune Responses To Hsv
Innate Immune Response
The innate immune system consists of a variety of components including neutrophils, natural killer cells, monocytes, dendritic cells, macrophages, and the complement cascade . It is the first line of defense against pathogens. A strong innate immune response to foreign antigens is essential to the development of the adaptive humoral and cellular responses of long-lasting immunity . Adjuvants are added to subunit vaccines to elicit an innate response for this purpose. Pattern recognition receptors on host cells allow for the detection and response to viral infections. On binding to pattern recognition receptors , signal transduction leads to the production of various proteins including interferons . Interferons are glycoprotein signaling molecules produced by infected cell lines. They act locally, priming viral defense mechanisms within local cells .
HSV-1 is known to have multiple ligands that bind TLRs, leading to activation of the NF-kB pathway . However, herpes simplex virus is also known to evade the innate immune responses, specifically TLR signaling and interferon production to further viral proliferation . Additionally, a critical aspect of the innate immune system that contributes to the adaptive response is antigen presentation. HSV infection can stimulate autophagy, leading to a more efficient presentation of antigens. However, HSV-1 ICP34.5 gene product antagonizes the response by binding Beclin 1 , essential to autophagy .
You May Like: How To Treat Genital Herpes Breakout
All About Synergy Pharmaceuticals Herpes Cure
Sydney, Australia Theres a long history of division and infighting between supporters of alternative medicine and the more traditional medical community. Patients turn to holistic treatments for several reasons among them, alternative medicines align with their beliefs, values, and philosophical approaches to health and life . They also believe that medications with natural ingredients are healthier and safer . However, medical professionals question their efficacy, often discrediting the alternative medicine community as one that relies more on hopes and irrational beliefs than science. But a new, viable herpes cure from Synergy Pharmaceuticals in Australia could shift the dynamic of the argument, giving alternative medicine a much-needed vote of confidence.
A natural cure for herpes
On Synergy Pharmaceuticals official website , there are several testimonials from happy consumers. One customer, Troy, tested negative for herpes after just three months on the companys Combination Herpes Treatment. Shamira K. tested negative for herpes simplex virus 2 before she reached the 90-day mark. Jennifer M. was herpes-free after 7 months. More and more people are springing up on social media, courageous enough to tell their personal ordeal and success stories. At what seems a groundswell of newly cured cases every day.
Conventional medical professionals take aim
Why Synergy Pharmaceuticals cure matters
Looking ahead
The Development Of Treatment For Hsv
The herpes simplex virus has been in existence for over 2,000 years. The ancient Romans were so afraid of the condition, that Emperor Tiberius placed a ban on kissing, to reduce the possibility of his subjects spreading cold sores. Over the centuries, however, genital herpes became more prevalent, specifically among prostitutes. In fact, genital herpes came to be known as a vocational disease of women. Unfortunately, due to the lack of modern medicine, those that suffered from oral or genital herpes didnt have any treatment options.
It wasnt until 1960 that herpes medication was developed. It was initially a trial-and-error period where the results of the experiments varied across the board. In the following decades, there has been some progress in the search for a cure for herpes prescription medication is now available to reduce the impact of herpes.
Synergys solution to completely eliminating herpes
Synergys combination is one of the most powerful all-natural antiviral treatments developed. it improves and boosts the immune system to target and eliminate the herpes virus.
The EAF is a key product that facilitates the production of T Cells. T Cells are integral in treating and eliminating the herpes viral cells within both, the sacral ganglion as well as the trigeminal ganglion. These break down the herpes viral envelope, which then destroys the viral cells.
Don’t Miss: Does Dr Sebi Cure Herpes
Synergy Pharmaceuticals Herpes Treatment Renews Hope For A Cure And Ignites Debate In Pharmaceutical Industry
For those who contract herpes simplex in any of its forms, the virus is generally considered a lifetime sentence defined by unpredictable flareups and endless rounds of medication. However, a major treatment breakthrough from Australian research and product development company Synergy Pharmaceuticals suggests that herpes may be curable. News of this medical breakthrough could lead to a windfall for Synergy, but in addition to its impending success, the company is also tasked with overcoming criticism from many within the medical community.
A young company restores hope
Whereas previous drug trials focused on finding a vaccine for the herpes virus, Synergy Pharmaceuticals focused on finding a holistic solution for existing herpes patients, and the approach generated unprecedented results.
The company used a five-part treatment, the Combination Herpes Treatment, crafted from L-Lysine, Tribulus, Astragalus, Rhodiola, and a Unique Amino Formula. The special combination of natural ingredients generated T cells which helped break down herpes viral envelope and weakened the virus to the point of erasure. Essentially, the combination treatment prevented cell-to-cell infection and suppressed the virus overall activity.
Synergy Pharmaceuticals research showed a significant result in 72% of test cases. Patients involved in the study had been infected for several years and ingested the five core compounds as directed for six months.
The race for a cure
Media Contact
Why Trust Synergy Pharmaceuticals Regarding Our Herpes Treatment
For years, we have been told that there was no cure for the herpes simplex virus. Attempts to formulate vaccines have repeatedly proven ineffective, during which time the virus has continued to spread often undetected. The most that an HSV sufferer could expect was a cold sore treatment to suppress oral sores, or a genital herpes treatment that could reduce pain, itchiness, and irritation.
At Synergy Pharmaceuticals, we think we have discovered something that will change these conversations for good. While our treatment approach is new, we have also gone to great lengths to test it, to monitor subjects on an ongoing basis, to look out for potential side effects and to make sure we are not just achieving a temporary diminishing of HSV viral activity. Our goal now is to spread the word: to take our treatment global, to share the science behind our 100 per cent natural approach and to push forward towards a future where herpes simplex virus might be eradicated from the surface of the globe. A world without herpes is possible, and it starts today. Contact us today to learn more.
100% Guaranteed
Don’t Miss: How To Get Pregnant With Herpes
Clinical Trials: Key To Genital Herpes Research
Although these new genital herpes treatments are just on the horizon, it may be years before any are available to consumers.
The process of introducing a new treatment to the public can be a long one. Before the FDA approves a drug, it must go through rigorous clinical trials, which are divided into three phases. In phase I, researchers try to find out if the drug is safe for people to take. If the drug is deemed safe, it may go on to phase II, when researchers aim to determine if the drug works as it should. They also collect more safety data. In phase III trials, they expand their research to include more patients in more places.
To conduct a clinical trial, scientists need people to participate voluntarily. Clinical trials often involve thousands of patients who volunteer to take the experimental drug. The FDA and an independent review board carefully monitor every aspect of the trial. There are rules the researchers must follow to ensure that their work is scientifically correct and ethically sound. Study volunteers have clearly defined rights, such as the right to drop out of the trial at any time.
Recommended Reading: What To Use For Herpes Outbreak